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Aim: To establish the effect of three single chemotherapeutic agents on the growing skeleton, male Wistar rats were studied.Methods: From the age of 4 weeks the rats were given iv doxorubicin (DOX) 15mg/m 2 body surface area (BSA), methotrexate (MTX) 60mg/m 2 BSA or cisplatin (CDDP) 7.5mg/m 2 BSA. One non-treated control group was fed ad libitum (ad lib) and for every drug-treated...