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In this study, we confirmed that combining HHT with ACR can result in synergistic cytotoxicity to AML cells in vitro and in vivo. Combining HHT and ACR simultaneously inhibited PI3K/AKT and WNT/β-catenin signaling in AML cells. Significant increases in growth inhibition and apoptosis were induced by an AKT inhibitor when the WNT3A gene of THP-1 cells was silenced. HHT+ACR could synergistically induce...
When a dynamic system to be analyzed is subjected to velocity-dependent force(s), a quadratic eigenproblem arises. This paper presents an efficient algorithm for the calculation of the eigensolutions' sensitivity in quadratic eigenproblems, the attention being focused on how to extract eigenvalue and eigenvector derivatives of a general non-defective eigenpair directly in the configuration space....
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