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Most studies have reported an up-regulation of retinoic acid receptor (RAR) mRNA expression by all-trans retinoic acid (RA). We aimed to study the effect of RA on RAR protein levels in MCF-7 human breast cancer cells. Incubation of these cells with 10 −6 M RA induced a rapid breakdown of both RARα and RARγ in spite of the accumulation of their mRNAs. Proteasome specific inhibitors blocked...