Search results for: Mati Lopez-Grancha

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article

Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models

Martine Latta‐Mahieu, Bradford Elmer, Alexis Bretteville, Yaming Wang, more

Glia > 66 > 3 > 492 - 504

Chronic inflammation represents a central component in the pathogenesis of Alzheimer's disease (AD). Recent work suggests that breaking immune tolerance by Programmed cell Death‐1 (PD1) checkpoint inhibition produces an IFN‐γ‐dependent systemic immune response, with infiltration of the brain by peripheral myeloid cells and neuropathological as well as functional improvements even in mice with advanced...

article

TAU PATHOLOGY PROPAGATES THROUGH NEURAL NETWORKS IN TAU22 MICE AFTER INJECTION OF SYNTHETIC TRUNCATED TAU AGGREGATES IN DORSAL HIPPOCAMPUS

Véronique Mary, Marie-Carmen Obinu, Jean-Marie Miquet, Stéphanie Eyquem, more

Alzheimer's & Dementia > 2017 > 13 > 7(S) > P1277-P1278

article

SELECTIVE PKR INHIBITION RESCUES MEMORY DEFICITS AND NEURODEGENERATION IN MOUSE MODELS WITH PATHOLOGICAL FEATURES OF ALZHEIMER’S DISEASE

Delphine Ibghi, Mati Lopez-Grancha, Patrick Bernardelli, Nicolas Moindrot, more

Alzheimer's & Dementia > 2017 > 13 > 7(S) > P952

article

SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents

Guy Griebel, Philippe Pichat, Marie-Pierre Pruniaux, Sandra Beeské, more

Pharmacology, Biochemistry and Behavior > 2012 > 102 > 2 > 203-214

SAR110894 is a novel histamine H ₃ -R ligand, displaying high and selective affinity for human, rat or mouse H ₃ -Rs. SAR110894 is a potent H ₃ -R antagonist at native receptors, reversing R-α-methylhistamine-induced inhibition of electrical field stimulation contraction in the guinea-pig ileum. Additionally, SAR110894 inhibited constitutive GTPγS binding at human H ₃ ...

article

Differential effects of morphine and LiCl on schedule-induced polydipsia

Ashley Myracle, Mati Lopez-Grancha, Pilar Flores, John Glowa, more

Pharmacology, Biochemistry and Behavior > 2005 > 80 > 1 > 195-202

Lithium chloride (LiCl) and morphine both produce a conditioned taste avoidance response, while only LiCl is able to elicit a conditioned rejection response (taste reactivity), indicating that the effects of conditioning are drug and preparation dependent. The present experiments extend this assessment to another behavioral preparation, schedule-induced polydipsia (SIP), by examining the ability of...

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Search results for: Mati Lopez-Grancha

Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models

TAU PATHOLOGY PROPAGATES THROUGH NEURAL NETWORKS IN TAU22 MICE AFTER INJECTION OF SYNTHETIC TRUNCATED TAU AGGREGATES IN DORSAL HIPPOCAMPUS

SELECTIVE PKR INHIBITION RESCUES MEMORY DEFICITS AND NEURODEGENERATION IN MOUSE MODELS WITH PATHOLOGICAL FEATURES OF ALZHEIMER’S DISEASE

SAR110894, a potent histamine H3-receptor antagonist, displays procognitive effects in rodents

Differential effects of morphine and LiCl on schedule-induced polydipsia

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