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Mice homozygous for the mutantFasgenelprdevelop generalized lymphoproliferation and produce autoantibodies resembling those found in human SLE. We have previously shown that these autoantibodies are produced by B2 cells rather than B1 cells and that the autoantibody-producing B cells are intrinsically abnormal. We investigated further thelprB cell with a large panel of antibodies to B-cell surface...