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We investigated whether alcohol pretreatment sufficient to cause fatty liver change would affect the disposition of bupivacaine after i.v. administration in pigs. Twelve male pigs (22-26 kg) were randomly divided into two groups of six each. Group A received ethanol (1 g kg -1 day -1 ) via an intragastric tube for 16 days. Group D received an equal volume of isocaloric dextrose...