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Influenza A viruses (IAVs) utilize sialylated host glycans as ligands for binding and infection. The glycan-binding preference of IAV hemagglutinin (HA) is an important determinant of host specificity. Propagation of IAV in embryonated chicken eggs and cultured mammalian cells yields viruses with amino acid substitutions in the HA that can alter the binding specificity. Therefore, it is important...
We demonstrate an abrupt drop in insertion loss (up to 21 dB) at a critical RF (10 GHz) power in 2-port series co-planar waveguides incorporating vanadium dioxide thin films. We rigorously determine the critical delivered power for switching by calculating the waveguide reflection coefficients from a lumped element model. Through analysis of the critical RF power, we find definitively that the drop...
A large-signal model for GaN HEMT devices is presented for use in medium power (1–2 W), S-band PA applications. The emphasis of the model is on quick extraction from standard measurements to facilitate research in this new operating regime for GaN HEMT devices. The entire model is extracted using small-signal S-parameter measurements under a small variety of bias conditions and DC IV characteristics...
Through its transcriptional activities, the proto-oncoprotein c-jun can regulate cellular proliferation, survival, and differentiation. We have established a novel yeast assay that screens for repressors of c-jun transcriptional activity. This screen led to the identification of a ubiquitously expressed novel RING zinc finger protein, termed Makorin RING zinc finger protein 1 (MKRN1), recently shown...
The human androgen receptor (hAR) is a member of the nuclear receptor superfamily and functions as a ligand-inducible transcription factor. We have previously proposed that c-Jun mediates the transcriptional activity of this receptor. The modular nature of hAR was used in this study to generate several fusions with the heterologous DNA-binding domain of the yeast transcription factor GAL4 in an attempt...
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