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Multiple d‐amino acids are present in mammalian cells, and these compounds have distinctive physiological functions. Among the free d‐amino acids identified in mammals, d‐aspartate plays critical roles in the neuroendocrine and endocrine systems, as well as in the central nervous system. Mammalian cells have the molecular apparatus necessary to take up, degrade, synthesize, and release d‐aspartate...
d‐Aspartate oxidase (DDO) is a degradative enzyme that acts stereospecifically on free acidic D‐amino acids such as d‐aspartate and d‐glutamate. d‐Aspartate plays an important role in regulating neurotransmission, developmental processes, hormone secretion, and reproductive functions in mammals. In contrast, the physiological role of d‐glutamate in mammals remains unclear. In Caenorhabditis elegans...
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