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Posaconazole, a triazole antifungal agent with proven efficacy for prophylaxis and treatment of fungal infections, is often limited by poor absorption. We report on five consecutive patients who received posaconazole along with a care bundle intended to increase absorption by addressing gastric pH, co‐administration with food, dividing doses and avoiding drug interactions. Each patient yielded multiple...
The downhole vertical accelerometer array VSAP near Paducah, KY, consists of three-component accelerometers at the surface, the top of the McNairy Formation (−41 m), and the top of the Paleozoic bedrock (—99 m). The array is at the northern end of the Mississippi Embayment, and it was installed to verify the ground-motion modeling for the site, assuming a significant earthquake in the New Madrid Seismic...
One hundred thirty-four horizontally polarized shear-wave (SH) seismic soundings have been performed in the Jackson Purchase Region of western Kentucky. These data have been used to derive the thicknesses and shear-wave velocities for the various impedance horizons in the upper 30 m of the soil column at each site for the purposes of general land-use management and loss estimation in the event of...
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