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The aim of the study was to investigate and compare the clinical manifestations between HLA‐B27+ and HLA‐B27− ankylosing spondylitis (AS) patients in order to obtain knowledge of the impact of HLA‐B27 status on AS, and to inform clinical treatment. A nationwide epidemiological investigation was performed from November 2008 to October 2010. The demographic data and clinical characteristics, and the...
This study aimed at examining the association of the single nucleotide polymorphism (SNP) in the protein tyrosine phosphatase gene (PTPN22) with the risk of rheumatoid arthritis (RA) in a Chinese population. A total of 200 RA patients and age and gender‐matched healthy controls were recruited. Their genotypes and allelic frequency were determined by the TaqMan‐MGB probe‐based polymerase chain reaction...
Keloids are common abnormal raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There is strong evidence suggesting a genetic susceptibility in individuals affected by keloids including familial heritability, common occurrence in twins, and high prevalence in certain ethnic populations. Human leukocyte antigens (HLAs) have been proposed to modulate the immune response...
A novel human leukocyte antigen (HLA)‐B allele, B*5535, has been identified in a Chinese individual by sequence‐based typing, which has seven nucleotide changes from the closest matching allele B*5502 resulting in two amino acids changes: 69 Glu→Met; 70 Glu→Ala.
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