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Bone morphogenetic protein (BMP) has the ability to induce ectopic bone, while the action of transforming growth factor β (TGF β) is to stimulate proliferation of osteoblasts and chondrocytes as well as the production of extracellular matrix. The aim of the present study was to study their synergistic actions in bone formation. Three kinds of complexes, recombinant human BMP2 (rhBMP2), TGF β and rhBMP2/TGF...