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Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets of Langerhans, followed by the selective and progressive destruction of insulin-secreting β-cells. Islet infiltrating leukocytes secrete cytokines including IL-1β and IFN-γ, which contribute to β-cell death. In vitro evidence suggests that cytokine-induced activation of the transcription factor NF-κB...