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Acidic macromolecules have consistently been associated with biological mineral formation in vivo. Several of these macromolecules have been shown to induce mineral formation from metastable solutions when attached to a substrate. However, when free in solution, the same molecules inhibit mineral formation. These results indicate that the surface plays an important role in biomineralization. We have...
The spatial and temporal relationships of mineral deposition between matrix vesicles and type I collagen fibrils have been studied in the turkey leg tendon by electron microscopy of cross sections and serial longitudinal thin sections and by electron tomography of longitudinal thick sections. Serial sectioning and electron tomography allow three-dimensional analysis of spatial relationships, overcoming...
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