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It is commonly assumed that the physiological isoform of prion protein, PrP C , is cleaved during its normal processing between residues 111/112, whereas the pathogenic isoform, PrP Sc , is cleaved at an alternate site in the octapeptide repeat region around position 90. Here we demonstrated both in cultured cells and in vivo, that PrP C is subject to a complex set of...
L'utilisation de cultures cellulaires permet d'aborder la plupart des questions scientifiques relatives aux recherches sur les encephalopathies spongiformes transmissibles. Ces modeles in vitro comprennent principalement des lignees infectees de facon chronique par les prions ou qui expriment des quantites variables de proteines du prion normales, mutees ou chimeriques. Ces cultures cellulaires ont...
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