Hans J. Roethig

article

Factors affecting exposure to nicotine and carbon monoxide in adult cigarette smokers

Raheema Muhammad-Kah, Qiwei Liang, Kimberly Frost-Pineda, Paul E. Mendes, more

Regulatory Toxicology and Pharmacology > 2011 > 61 > 1 > 129-136

Exposure to cigarette smoke among smokers is highly variable. This variability has been attributed to differences in smoking behavior as measured by smoking topography, as well as other behavioral and subjective aspects of smoking. The objective of this study was to determine the factors affecting smoke exposure as estimated by biomarkers of exposure to nicotine and carbon monoxide (CO). In a multi-center...

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Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers

Hans J. Roethig, Tamara Koval, Raheema Muhammad-Kah, Yan Jin, more

Regulatory Toxicology and Pharmacology > 2010 > 57 > 2-3 > 333-337

Previous studies indicate that cigarette smokers have a 5–30% higher white blood cell counts (WBC) compared to non-smokers and higher red blood cell counts. Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platelets, red blood cell count (RBC) and hematocrit in adult cigarette smokers three days after using an electrically...

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The effect of menthol containing cigarettes on adult smokers’ exposure to nicotine and carbon monoxide

Jingzhu Wang, Hans J. Roethig, Scott Appleton, Michael Werley, more

Regulatory Toxicology and Pharmacology > 2010 > 57 > 1 > 24-30

There is limited information comparing biomarkers of exposure (BOE) to cigarette smoke in menthol (MS) and non-menthol cigarette smokers (NMS). Objective: To compare BOE to nicotine and carbon monoxide in MS and NMS. Methods: Cross-sectional, observational, ambulatory, multi-centre study in 3341 adult cigarette smokers. Nicotine equivalents (NE) in 24h urine, NE/cigarette, COHb and serum cotinine...

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The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US

Paul Mendes, Qiwei Liang, Kimberly Frost-Pineda, Sagar Munjal, more

Regulatory Toxicology and Pharmacology > 2009 > 55 > 1 > 17-27

Comprehensive data on human exposure to smoke constituents from different machine-measured tar yield cigarettes is limited. Methods: This study used a stratified, cross-sectional, multi-center design to estimate biomarkers of exposure (BOE) from nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), pyrene, CO, acrolein, and 1,3-butadiene and their relationship to tar yield categories of...

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Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS)

Kimberly Frost-Pineda, Barbara K. Zedler, Qiwei Liang, Hans J. Roethig

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 118-121

This sub-study of a randomized, controlled, forced-switching, open-label, parallel-group, clinical study compared environmental tobacco smoke (ETS) produced when 60 male and female adult smokers switched to a third-generation electrically heated cigarette smoking system (EHCSS), continued to smoke a conventional cigarette (CC), or stopped smoking (No-smoking). Concentrations of air constituents including...

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Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

Kimberly Frost-Pineda, Barbara K. Zedler, Douglas Oliveri, Shixia Feng, more

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 104-110

This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 100 male and female adult smokers evaluated 12 biomarkers of tobacco smoke exposure. We measured exposure to the following smoke constituents: nicotine, pyrene, tobacco-specific nitrosamines, three aromatic amines, carbon monoxide, benzene, acrolein, crotonaldehyde, and 1,3-butadiene. After baseline exposure...

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12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

Kimberly Frost-Pineda, Barbara K. Zedler, Douglas Oliveri, Qiwei Liang, more

Regulatory Toxicology and Pharmacology > 2008 > 52 > 2 > 111-117

This randomized, controlled, forced-switching, open-label, parallel-group, single-center study in 90 male and female adult smokers evaluated six biomarkers of tobacco smoke exposure over a 12-week period of unrestricted smoking in the participants’ normal life setting. Baseline biomarker levels were measured, then participants were randomly assigned to switch to an electrically heated cigarette smoking...

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The effect of cigarette burn time on exposure to nicotine and carbon monoxide in adult smokers

Qiwei Liang, Hans J. Roethig, Peter J. Lipowicz, Yan Jin, more

Regulatory Toxicology and Pharmacology > 2008 > 50 > 1 > 66-74

Cigarette burn time (CBT), conventionally defined as the time a cigarette burns during smoking, can be affected by cigarette design and smoking behavior. A previous study showed a strong negative correlation between CBT and nicotine yield under machine smoking conditions. This study for the first time examined the relationship of CBT and exposure to nicotine and carbon monoxide in adult smokers in...

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Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers

Shixia Feng, Sunil Kapur, Mohamadi Sarkar, Raheema Muhammad, more

Toxicology Letters > 2007 > 173 > 2 > 101-106

Urinary excretion of nicotine and its five major metabolites (nicotine-N-glucuronide, cotinine, cotinine-N-glucuronide, trans-3′-hydroxycotinine, and trans-3′-hydroxycotinine-O-glucuronide), expressed as nicotine equivalents (NE), has been used as a biomarker of smoking-related nicotine exposure. In this open-label, single center study, we investigated the relationship between nicotine retention from...

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CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers

Mohamadi Sarkar, Regina Stabbert, Robin D. Kinser, Jan Oey, more

Toxicology and Applied Pharmacology > 2006 > 213 > 3 > 198-206

Some aromatic amines are considered to be putative bladder carcinogens. Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. One of the goals of this study was to determine intra- and inter-individual variability in 3-ABP and 4-ABP Hb adducts and to explore the predictability of ABP Hb adduct...

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Search results for: Hans J. Roethig

Factors affecting exposure to nicotine and carbon monoxide in adult cigarette smokers

Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers

The effect of menthol containing cigarettes on adult smokers’ exposure to nicotine and carbon monoxide

The relationship between smoking machine derived tar yields and biomarkers of exposure in adult cigarette smokers in the US

Environmental tobacco smoke (ETS) evaluation of a third-generation electrically heated cigarette smoking system (EHCSS)

Short-term clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

12-Week clinical exposure evaluation of a third-generation electrically heated cigarette smoking system (EHCSS) in adult smokers

The effect of cigarette burn time on exposure to nicotine and carbon monoxide in adult smokers

Respiratory retention of nicotine and urinary excretion of nicotine and its five major metabolites in adult male smokers

CYP1A2 and NAT2 phenotyping and 3-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in smokers and non-smokers

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