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High-resolution multicolour banding FISH (mBAND) and multiplex FISH (mFISH) were used to analyse the aberrations of chromosome 1 in irradiated-AG01522 human primary fibroblasts. The cells were exposed to 1Gy of a panel of radiation of different qualities, such as X-rays, low-energy protons (28keV/μm), helium-ions (62keV/μm) and carbon-ions (96 and 252keV/μm). mBAND and mFISH analysis in calyculin-A...
Mitochondria are the main cellular source of Reactive Oxygen Species (ROS). Alterations of mitochondrial metabolism and consequent loss of mitochondrial membrane potential may lead to redox imbalance and in turn to DNA damage, chromosomal instability and apoptosis. On the other hand, impaired mitochondrial functions may either exacerbate the detrimental effects of geno- and cytotoxic agents or may...
The radiation induced free radical damage in Chinese hamster lung fibroblast V-79 cells stored in DMEM culture medium containing 10% DMSO has been investigated by matrix EPR spectroscopy in connection with the H 2 O/DMSO binary phase diagram. A major part of the indirect effect is due to radicals from the DMSO·3H 2 O phase in the freezing medium, which are released on warming in the...
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