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Taking advantage of the unique structure feature of cucumber mosaic virus (CMV), we have anchored folic acid (FA) as targeting moiety on the rigid CMV capsid and loaded significant amount of doxorubicin (Dox) into the interior cavity of CMV through the formation of Dox–RNA conjugate to provide a nanosized control delivery system for cancer therapy. The FA–CMV–Dox assemblies were characterized using...