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Continuous administration of soluble protein antigen to BALB/c mice inhibits the default development of Th1 and induces selective differentiation of Th2 cells. We now show that pretreatment with soluble protein decreases by over 5-fold the expression of IL-12 receptor on antigen-primed CD4 + T cells. The effect of IL-12 administration on tolerance induction in Th1 cells and on Th2 cell differentiation...
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