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We diagnosed two Chinese hereditary PC deficiency families and identified two novel compound heterozygous mutations (p.Arg194Cys/Gly324Ser and p.Glu274X/Asp297His) in the protein C (PROC) gene. The probands were classified as types I and II PC deficiency. The aim of this article is to access the influence of the mutations on PC activity, antigen and protein structure, and to evaluate whether there...
The paper uses power-law frequency distribution, power spectrum analysis, detrended fluctuation analysis, and surrogate data testing to evaluate outpatient registration data of two hospitals in China and to investigate the human dynamics of systems that use the “first come, first served” protocols. The research results reveal that outpatient behavior follow scaling laws. The results also suggest that...
According to the real practice of hospital outpatient operating rooms, the problem of process and capacity planning is analyzed by considering the rule of balancing and increasing the resource utilization; based on queuing theory, this paper brings out the outpatient operating room process upswing plan and establishes simulation models; then, this paper puts forward the total cost objective function...
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