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The passage of Ca2+ ions through voltage-gated Ca2+ channels triggers a wide range of signaling pathways but also fundamentally regulates further Ca2+ influx through these channels. Cav1.2 (L-type) and Cav2.1 (P/Q-type) channels undergo a dual feedback regulation by Ca2+, which is manifested as enhanced facilitation and inactivation of Ca2+ currents compared to Ba2+ currents. Ca2+-dependent facilitation...
Query rewriting has been used as a query optimization technique for several decades to reduce the computational cost of a query. Traditional problems in query rewriting include in particular query optimization au][28, 60, 6] and rewriting queries using views [40, 7]. Most of these works deal with the problem of maintaining the exact original interface (schema) and extent of a given query while optimizing...
The initial stages of fetal development require that blood oxygenation occur through the placenta rather than the non functioning lungs. As a result the fetal circulatory system develops a temporary shunt between the aorta and pulmonary artery, known as the ductus arteriosis (DA). This study utilizes CFD techniques to analyze the flow behavior in the aortic isthmus neighboring the DA. The geometry...
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