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This study examined changes in protein kinase C (PKC) isoforms in rodent fibroblasts (rat F111 and mouse NIH3T3), transformed by the polyoma virus middle T antigen (mT) and undergoing apoptosis in response to teniposide (VM26). The mT-transformed cells up-regulated PKC δ and down-regulated both PKC and PKC λ expression, and were more sensitive to the drug than their non-transformed counterparts...
In order to establish what role members of the activating protein-1 (AP-1) gene families, i.e., c-fos,c-jun, junB,andjunD,play in thymic apoptosis, we have analyzed changes in their expression in response to three different agents: a glucocorticoid analog dexamethasone, an inhibitor of topoisomerase II teniposide VM26, and gamma radiation. All three agents induced thymic death at a similar rate and...
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