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Benzodiazepine poisoning causes coma and respiratory depression. Our objective was to determine whether, and to what extent, arterial blood gas disturbances correlated with blood or cerebral kinetics of midazolam. A 160mgkg −1 single dose of midazolam was infused intravenously over 20min in catheterized male Sprague–Dawley rats. Midazolam kinetics was simultaneously determined in plasma and...