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Increasing age is associated with a decline in adaptive immunity and poorer responses to vaccination. While specific immune defects have clearly been defined in the naïve T-cell pool of aged individuals, much less is known about the memory T-cell pool. Current data suggest that T-cell memory generated in an aged individual has a reduced capacity to mediate recall responses due primarily to defects...
The recent outbreaks of H5N1 avian and H1N1 swine-origin influenza viruses highlight the urgent need for vaccine strategies able to confer broad host immunity against both seasonal and pandemic strains of influenza. As the lung mucosa is the first barrier against pulmonary influenza infection, an effective influenza vaccine strategy should elicit anti-viral immune responses in the respiratory tract...
It is well established that increasing age is associated with a decreased capacity of the immune system to mediate effective immune responses to vaccination and invading pathogens. Because of the inherent limitations of conducting experiments in humans, much of what we have learned is owed to the utility of experimental mouse models of aging. Recent studies performed in the mouse have demonstrated...
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