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A sexual dimorphism exists in the incidence and prevalence of coronary artery disease—men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity. We genotyped 11 markers of the male-specific region of the Y chromosome in 3233 biologically unrelated British men from three cohorts: the British...
Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ receptor (NOP). In this study using Chinese hamster ovary (CHO) cells expressing the human NOP (CHO hNOP ) and GTPγ 35 S binding and cAMP inhibition assays, we have characterised a novel N/OFQ ligand, [(pF)Phe 4 ]N/OFQ-(1-13)NH 2 , ([(pF)Phe 4 ]). [(pF)Phe 4 ] was...
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