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The problems inherent in the enzymatic and chemical synthesis of S-adenosyl-l-methionine (SAM) led us to develop an efficient, simple method for the synthesis of large amounts of labeled SAM. Previously, we reported that the problem of product inhibition of E. coli SAM synthetase encoded by the metK gene was successfully overcome in the presence of sodiump -toluenesulfonate (pTsONa). This research...