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The etiology of osteoporosis is multifactorial, but there is evidence from both animal and human studies that the volume of marrow adipose tissue increases when bone volume is reduced in osteoporosis. The cell-related mechanism that may account for this inverse relationship between the volume of marrow adipose tissue and bone remains to be clarified, although it is known that both adipocytes and osteoblasts...
Previous studies have shown that IL 6, a multifunctional cytokine, is secreted by bone marrow-derived stromal cells and may affect osteoclast formation. IL 11 is another pleiotrophic cytokine which was originally identified and cloned from bone marrow stromal cells and there is increasing evidence that it may also have effects on cells of the osteogenic lineage in addition to its well-documented...
In recent years it has been established that osteoblasts and their precursors are derived from pluripotential stem cells in the marrow tissue of long bones or perisoteal fibroblasts. The aim of this study was to determine the in vitro osteogenic potential of other cell types, in particular those involved in the early endochondral sequence. Cells were derived from preosseus tissues of deer antler...
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