Search results for: Hiroshi Fujishima

Items from 1 to 20 out of 43 results

article

Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis

Naoko Okada, Hiroyuki Yazu, Eisuke Shimizu, Kazumi Fukagawa, more

Allergy > 78 > 1 > 319 - 321

article

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep

Yasutaka Niwa, Genki N. Kanda, Rikuhiro G. Yamada, Shoi Shi, more

Cell Reports > 2018 > 24 > 9 > 2231-2247.e7

Sleep regulation involves interdependent signaling among specialized neurons in distributed brain regions. Although acetylcholine promotes wakefulness and rapid eye movement (REM) sleep, it is unclear whether the cholinergic pathway is essential (i.e., absolutely required) for REM sleep because of redundancy from neural circuits to molecules. First, we demonstrate that synaptic inhibition of TrkA+...

article

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

Yuta Shinohara, Yohei M. Koyama, Maki Ukai-Tadenuma, Takatsugu Hirokawa, more

Molecular Cell > 2017 > 67 > 5 > 783-798.e20

Temperature compensation is a striking feature of the circadian clock. Here we investigate biochemical mechanisms underlying temperature-compensated, CKIδ-dependent multi-site phosphorylation in mammals. We identify two mechanisms for temperature-insensitive phosphorylation at higher temperature: lower substrate affinity to CKIδ-ATP complex and higher product affinity to CKIδ-ADP complex. Inhibitor...

article

Japanese guidelines for allergic conjunctival diseases 2017

Etsuko Takamura, Eiichi Uchio, Nobuyuki Ebihara, Shigeaki Ohno, more

Allergology International > 2017 > 66 > 2 > 220-229

The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines for Clinical Management of Allergic Conjunctival Disease (Second Edition) revised in 2010. Allergic conjunctival disease is defined as “a conjunctival inflammatory disease associated with a Type I allergy accompanied...

article

Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases

Dai Miyazaki, Atsuki Fukushima, Yuichi Ohashi, Nobuyuki Ebihara, more

Ophthalmology > 2017 > 124 > 3 > 287-294

To evaluate the effects of 0.1% topical tacrolimus alone or in combination with steroids for the treatment of shield ulcers and corneal epitheliopathy in patients with refractory allergic ocular diseases.Open cohort study.Patients with refractory allergic conjunctivitis epitheliopathy, shield ulcers, or corneal plaques (N = 791).The 791 patients were treated with topical tacrolimus alone or in combination...

article

Efficacy and safety of an eye wash solution in allergic conjunctivitis after conjunctival allergen challenge

Hiroyuki Yazu, Murat Dogru, Yukihiro Matsumoto, Hiroshi Fujishima

Annals of Allergy, Asthma & Immunology > 2016 > 117 > 5 > 565-566

article

The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases

Hiroshi Fujishima, Naoko Okada, Kenji Matsumoto, Kazumi Fukagawa, more

Journal of Allergy and Clinical Immunology > 2016 > 138 > 2 > 459-467.e2

Chronic ocular allergic diseases such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are accompanied by serious comorbidities; however, the underlying pathogenesis remains obscure. Furthermore, diagnosing conjunctival lesions in patients with atopic dermatitis and estimating the severity in AKC are important for the treatment of ocular allergic diseases.We addressed whether...

article

Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals

Fumiya Tatsuki, Genshiro A. Sunagawa, Shoi Shi, Etsuo A. Susaki, more

Neuron > 2016 > 90 > 1 > 70-85

The detailed molecular mechanisms underlying the regulation of sleep duration in mammals are still elusive. To address this challenge, we constructed a simple computational model, which recapitulates the electrophysiological characteristics of the slow-wave sleep and awake states. Comprehensive bifurcation analysis predicted that a Ca²⁺-dependent hyperpolarization pathway may play a role in slow-wave...

article

Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene

Genshiro A. Sunagawa, Kenta Sumiyama, Maki Ukai-Tadenuma, Dimitri Perrin, more

Cell Reports > 2016 > 14 > 3 > 662-677

The identification of molecular networks at the system level in mammals is accelerated by next-generation mammalian genetics without crossing, which requires both the efficient production of whole-body biallelic knockout (KO) mice in a single generation and high-performance phenotype analyses. Here, we show that the triple targeting of a single gene using the CRISPR/Cas9 system achieves almost perfect...

article

Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge

Hiroshi Fujishima, Yuichi Ohashi, Etsuko Takamura

Annals of Allergy, Asthma & Immunology > 2014 > 113 > 4 > 476-481

Epinastine hydrochloride is a selective histamine H ₁ receptor antagonist that also inhibits IgE receptor-mediated histamine release from mast cells.To show the superiority of epinastine 0.05% ophthalmic solution (epinastine) to placebo ophthalmic solution (placebo) and noninferiority to olopatadine 0.1% ophthalmic solution (olopatadine) for cedar pollen antigen-induced ocular itching and...

article

Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan

Tatsuya Mimura, Takamichi Ichinose, Satoru Yamagami, Hiroshi Fujishima, more

Science of the Total Environment > 2014 > 487 > Complete > 493-499

Exposure to particulate matter less than 2.5μm in diameter (PM2.5) is associated with asthma and respiratory symptoms, but little is known about the influence of PM2.5 on allergic conjunctivitis. The purpose of this study was to examine the association of PM2.5 with outpatient attendance for allergic conjunctivitis.We conducted a time-series analysis of the association between outpatient attendance...

article

Sensitization to Asian dust and allergic rhinoconjunctivitis

Tatsuya Mimura, Satoru Yamagami, Hiroshi Fujishima, Hidetaka Noma, more

Environmental Research > 2014 > 132 > C > 220-225

Asian dust storms frequently occur in northeast Asia and the dust occasionally even spreads as far as North America during spring. Asian dust can be harmful to human health and the environment, and thus has become one of the most serious problems for Asian countries. In the present study, we evaluated sensitization to Asian dust in Japanese patients with rhinoconjunctivitis.In March 2011, a prospective,...

article

Cytokine Secretion Profiles In The Tears Of Patients With Chronic Allergic Conjunctivitis

Naoko Okada, Hiroshi Fujishima, Kazumi Fukagawa, Akio Matsuda, more

The Journal of Allergy and Clinical Immunology > 2014 > 133 > 2 Supplement > AB278

article

Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis

Hiroshi Fujishima, Kazumi Fukagawa, Naoko Okada, Yoji Takano, more

Annals of Allergy, Asthma & Immunology > 2013 > 111 > 2 > 126-131.e4

Eosinophils appear to be key cells in the pathogenesis of conjunctival inflammation in atopic keratoconjunctivitis (AKC). Chemoattractant receptor homologous molecule expressed on T _H 2 cells (CRTH2) mediates prostaglandin D ₂ (PGD ₂ )–dependent migration of eosinophils. However, it is unclear whether CRTH2/PGD ₂ -dependent eosinophil migration is upregulated in allergic...

article

Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium

Hiroshi Fujishima, Yoshiyuki Satake, Naoko Okada, Shinichi Kawashima, more

Annals of Allergy, Asthma & Immunology > 2013 > 110 > 1 > 39-43

Air pollution from road traffic is a serious public health problem. Epidemiologic studies have demonstrated adverse health effects associated with environmental pollution. Diesel exhaust is a major contributor to ambient particulate matter air pollution. We studied the effects of exposure to diesel exhaust particles on allergic conjunctivitis using cultured conjunctival epithelial cells obtained from...

article

In Vivo Confocal Microscopy Evaluation of Meibomian Gland Dysfunction in Atopic-Keratoconjunctivitis Patients

Osama M.A. Ibrahim, Yukihiro Matsumoto, Murat Dogru, Enrique Sato Adan, more

Ophthalmology > 2012 > 119 > 10 > 1961-1968

To clarify meibomian gland (MG) alterations in atopic keratoconjunctivitis (AKC) patients and compare the findings with obstructive MG dysfunction (MGD) patients and control subjects using in vivo confocal microscopy (CM). Prospective, controlled, single-center study. Twelve AKC patients (10 males, 2 females; mean age, 31.0±16.5 years), 12 obstructive MGD patients (7 males, 5 females; mean age,...

article

Tetrahydro-naphthols as orally available TRPV1 inhibitors

Klaus Urbahns, Takeshi Yura, Jang B. Gupta, Masaomi Tajimi, more

Bioorganic & Medicinal Chemistry Letters > 2012 > 22 > 10 > 3408-3411

Starting from a naphthol-based lead series with low oral bioavailability, we have identified potent TRPV1 antagonists with oral bioavailability in rats. These compounds emerged from SAR studies aimed at replacing the lead’s phenol structure whilst maintaining potency. Compound rac-6a is an orally available TRPV1 antagonist with single-digit nanomolar activity. The enantiomers show a low eudismic ratio...

article

Blood Level of Tacrolimus in Patients with Severe Allergic Conjunctivitis Treated by 0.1% Tacrolimus Ophthalmic Suspension

Nobuyuki Ebihara, Yuichi Ohashi, Hiroshi Fujishima, Atsuki Fukushima, more

Allergology International > 2012 > 61 > 2 > 275-282

To estimate the efficacy and safety of 0.1% tacrolimus ophthalmic suspension based on the blood level of tacrolimus in patients with severe allergic conjunctivitis.Fifty-two patients in whom topical anti-allergic agents had been ineffective were treated with 0.1% tacrolimus ophthalmic suspension twice daily for 12 weeks. Adverse drug reactions were monitored, as well as ocular symptoms and signs....

article

Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence

Klaus Urbahns, Takeshi Yura, Muneto Mogi, Masaomi Tajimi, more

Bioorganic & Medicinal Chemistry Letters > 2011 > 21 > 11 > 3354-3357

We have identified naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 by high throughput screening. The initial lead showed high clearance in rats and has been optimized by enhancing the acidity of the phenol group. Compound 6b has reduced clearance, improved potency and is active in rat cystometry models of urinary incontinence after intravenous administration.

article

Japanese Guideline for Allergic Conjunctival Diseases

Etsuko Takamura, Eiichi Uchio, Nobuyuki Ebihara, Shigeaki Ohno, more

Allergology International > 2011 > 60 > 2 > 191-203

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INFONA - science communication portal

Search results for: Hiroshi Fujishima

Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

Japanese guidelines for allergic conjunctival diseases 2017

Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases

Efficacy and safety of an eye wash solution in allergic conjunctivitis after conjunctival allergen challenge

The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases

Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals

Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene

Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge

Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan

Sensitization to Asian dust and allergic rhinoconjunctivitis

Cytokine Secretion Profiles In The Tears Of Patients With Chronic Allergic Conjunctivitis

Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis

Effects of diesel exhaust particles on primary cultured healthy human conjunctival epithelium

In Vivo Confocal Microscopy Evaluation of Meibomian Gland Dysfunction in Atopic-Keratoconjunctivitis Patients

Tetrahydro-naphthols as orally available TRPV1 inhibitors

Blood Level of Tacrolimus in Patients with Severe Allergic Conjunctivitis Treated by 0.1% Tacrolimus Ophthalmic Suspension

Naphthol derivatives as TRPV1 inhibitors for the treatment of urinary incontinence

Japanese Guideline for Allergic Conjunctival Diseases

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