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Recent studies have indicated postmenopausal women receiving hormone replacement therapy (HRT) have more adverse outcomes of peripheral arterial disease after vascular reconstruction, including increased intimal hyperplasia (IH) and restenosis. The major cellular processes contributing to IH pathogenesis are extracellular matrix (ECM) degradation and vascular smooth muscle cell (VSMC) proliferation,...
Open abdominal aortic aneurysm repair has been reported to be associated with impairment of sexual function in men, most likely because of autonomic nerve injury and pelvic blood flow changes. Endovascular aneurysm repair does not involve dissection in the area of the iliac bifurcation and therefore may be associated with lower incidence of sexual dysfunction as compared to open repair. We conducted...
Endovascular grafts (EVG) has been proposed as alternate therapy for treatment of vascular diseases. Graft structure is known to significantly influence healing and patency of standard bypass grafts (SBG), but its effect on EVG has not been previously reported. The aim of this study was to evaluate the effect of graft porosity and design on the healing of EVG.Ten dogs underwent infrarenal endovascular...
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