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The C-terminal domain of the Escherichia coli RNA polymerase α subunit (αCTD) plays a key role in transcription initiation at many activator-dependent promoters and at UP element-dependent promoters. This domain is connected to the α N-terminal domain (αNTD) by an unstructured linker. To investigate the requirements of the α inter-domain linker to support growth of E. coli, we utilised a recently...