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Objectives. To examine the significance of high-grade prostatic intraepithelial neoplasia (HGPIN) in biopsy specimens.Methods. We performed sextant biopsies on a series of 83 cystoprostatectomy specimens removed for bladder cancer. For each case the number of foci and volume of both HGPIN and prostate cancer were assessed in the prostatectomy specimens and compared with the number of biopsy specimens...
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