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Microsatellite instability (MSI) may be a molecular marker of colorectal tumor biology. We sought to evaluate the incidence and significance of MSI in an unselected colorectal cancer population. Colorectal cancer cases from a community health system were prospectively evaluated for MSI and patient outcomes monitored. Of 240 eligible, 140 underwent testing; 43 (31%) had high-frequency MSI (MSI-H)...