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HCV and HIV infections impair dendritic cell function. We evaluated the impact of HCV, HIV, and HCV-HIV infection on MDC–NK interactions by analyzing CD3 depleted PBMC for NK cell IFN-γ in response to IL-12 or poly (I:C). Purified MDC and NK cells were analyzed for TLR ligand-dependent, MDC-dependent NK activity. In HIV infection, IFN-γ production by CD3 depleted PBMC was reduced in response to poly...