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Major histocompatibility complex class I (MHC I) proteins provide protection from intracellular pathogens and cancer via each of a cell's MHC I molecules binding and presenting a peptide to cytotoxic T lymphocytes. MHC I genes are highly polymorphic and can have significant diversity, with polymorphisms predominantly localised in the peptide-binding groove where they can change peptide-binding specificity...
Abstract. Tapasin is a Mr 48,000 glycoprotein and has a specialized role in MHC classI-restricted antigen presentation. It is encoded by a gene which maps centromeric to the MHC classII region of human Chromosome 6 within 200 kb of HLA-DP. There is variable dependence upon tapasin for MHC classI expression among different MHC classI alleles. HLA-B*4402 and to a lesser extent HLA-A1 and B8 are tapasin...
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