The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The transcription factors called Activator Protein-1 (AP-1) collectively are dimers of two subunits derived from the Fos, Jun and ATF families1. Dimerization is mediated by the bzip domain of the subunits. For instance, cJun can dimerize with c-Fos or ATF-2. Each AP-1 dimer selects a closely related but distinct element in target promoters2,3. Nevertheless the function of these numerous AP-1 dimers...
A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine by an RNA–protein complex, consisting of PKA subunits and an A kinase anchoring protein (AKAP),...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.