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Background & Aims: Although interleukin (IL)-2 −/− and IL-2Rα −/− mice develop inflammatory bowel disease, IL-2Rβ −/− animals are apparently free of gut pathology. Intraintestinal T lymphopoiesis is reported to be impaired in IL-2Rβ −/− mice; we have determined whether this characteristic correlated with the apparent resistance of this mutant strain to intestinal...