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Receptory związane z białkami G (GPCRs) stanowią najliczniejszą i bardzo zróżnicowaną grupę receptorów błonowych odpowiedzialnych za przekazywanie sygnałów ze środowiska zewnętrznego do wnętrza komórki. GPCRs uczestniczą niemal w każdym aspekcie życia organizmów, regulując m. in. mechanizmy związane z odpowiedzią immunologiczną, zarówno u kręgowców, jak i bezkręgowców. W pracy opisano ogólną budowę...
The presented studies were aimed at exploring the role of neutral endopeptidase (NEP) in the function of colon cancer cell lines LS 180 and SW 620, derived from different grades and stages of tumor development. NEP silencing by siRNA resulted in decreased viability and proliferation accompanied by increased apoptosis in both cell lines. Additionally, cell cycle arrest at the G2/M phase was observed,...
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