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An array of 24 times 16 electrochemical sensors for detecting bio-molecules uses gold sensor electrodes added to a 0.5 mum CMOS process. Detection is based on time-resolved measurement of charge (chronocoulometry). A differential measurement technique uses a replica electrode and fast integration to suppress background offset signals
An 8 times 16 array of sensing micro-sites employs a fully-electrical label-free technique for DNA recognition using capacitance measurement and is fabricated in 0.5mum CMOS with added noble metal. Repeatability and parallel detection capability have been demonstrated. The DNA-chip is suitable for low-cost, fully-integrated point-of-care applications
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