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Myasthenia gravis (MG) is an archetypal autoimmune disease. The pathology is characterized by autoantibodies to the acetylcholine receptor (AChR) in most patients or to muscle‐specific tyrosine kinase (MuSK) in others and to a growing number of other postsynaptic proteins in smaller subsets. A decrease in the number of functional AChRs or functional interruption of the AChR within the muscle end plate...
IntroductionWe evaluated the response to immunosuppression in a case of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR)‐autoantibody myopathy.
MethodsT‐ and B‐cell subsets were determined by flow cytometry pre‐ and posttherapy.
ResultsBaseline immune profiling demonstrated strikingly elevated T‐follicular helper (Tfh) cells and plasmablasts. Immunosuppression resulted in clinical improvement...
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