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Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2 -Pro3 , Pro3 -Pro4 and Val6 -Pro7 replaced by their tetrazole analogues Ile2-Ψ[CN4]-Ala3 , Pro3 -Ψ[CN4]-Ala4 and Val6 -Ψ[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte...
The real contribution of moulds to the pathogenesis of allergic diseases remains unknown, although positive skin prick tests andlor spesific serum IgE to moki allergens can be detected in 1-5% of atopic patients. A significant problem in assesment of exposure to mould allergens, resulting with difficulty in standarization of methods. The aim of this work was to assess the concentration of spores of...
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