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High‐frequency oscillations (HFOs) are associated with normal brain function, but are also increasingly recognized as potential biomarkers of epileptogenic tissue. Considering the important role of interneuron activity in physiological HFO generation, we studied their modulation by midazolam (MDZ), an agonist of γ‐aminobutyric acid type A (GABAA)–benzodiazepine receptors. Here, we analyzed 80 intracranial...
Aim
A prolonged interval (>4 weeks) between short‐course radiotherapy (25 Gy in five fractions) (SCRT‐delay) and total mesorectal excision for rectal cancer has been associated with a decreased postoperative complication rate and offers the possibility of organ preservation in the case of a complete tumour response. This prospective cohort study systematically evaluated patient‐reported bowel...
Because oral pharmacological treatment of neocortical focal epilepsy is limited due to common systemic side effects and relatively low drug concentrations reached at the epileptic foci locally, application of antiepileptic agents directly onto the neocortical focus may enhance treatment tolerability and efficacy. We describe the effects of cortically applied sodium valproate (VPA) in two patients...
Epilepsiechirurgie ist bei therapierefraktärer fokaler Epilepsie bei ausgewählten Patienten in der Lage, Pharmakoresistenz zu überwinden und zu anhaltender Anfallsfreiheit zu führen. Ob Patienten mit mentaler Retardierung (MR) geeignete Operationskandidaten sind, wird kontrovers diskutiert und muss im Einzelfall entschieden werden. Ein Cochrane-Review von 2015 weist auf den mangelnden Wissensstand...
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