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Lateral hemisection of the spinal cord at the low thoracic level in rats causes severe deterioration of hindlimb locomotor movements followed by the substantial improvements of locomotor functions. However the rate and the level of this improvement remain disputable. In this study we investigated the time course of locomotor recovery analyzing spatial indices of locomotion obtained with CatWalk Gait...
There is considerable evidence from research in neonatal and adult rat and mouse preparations to warrant the conclusion that activation of 5-HT2 and 5-HT7 receptors leads to activation of the spinal cord circuitry for locomotion. Both types of receptors are involved in control of locomotor movements, but it is not clear how they are implicated in the responses to 5-HT agonists observed after spinal...
Lateral thoracic hemisection of the spinal cord in adult rats results in initial severe impairment of hindlimb movements followed by a relatively fast improvement of locomotor functions. There are data showing substantial or even complete recovery of locomotor performance within 21 – 30 days after spinal cord injury. In our previous study we showed that improvement of locomotor performance reached...