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High levels of prostaglandin E2 (PGE2) synthesis resulting from the up‐regulation of cyclooxygenase (COX)‐2 has been shown to be critical for the development of non‐melanoma skin tumors. This effect of PGE2 is likely mediated by one or more of its 4 G‐protein coupled membrane receptors, EP1‐4. A previous study showed that BK5.EP1 transgenic mice produced more carcinomas than wild type (WT) mice using...
Prostaglandin E2 (PGE2) has been shown to promote the development of murine skin tumors. EP1 is 1 of the 4 PGE2 G‐protein‐coupled membrane receptors expressed by murine keratinocytes. EP1 mRNA levels were increased ∼2‐fold after topical treatment with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) or exposure to ultraviolet (UV) light, as well as increased ∼3‐ to 12‐fold in tumors induced by 7,12‐dimethyl‐benz[...
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