Search results for: Prem P. Chapagain

Items from 1 to 11 out of 11 results

article

Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation

Yogesh Narkhede, Roopashi Saxena, Tej Sharma, Jacob P. Conarty, more

The Ebola virus (EBOV) is a lipid‐enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the matrix protein, VP40, which is a peripheral protein that associates with anionic lipids at the inner leaflet of the plasma membrane. VP40 is sufficient to form virus‐like particles (VLPs) from cells, which...

article

Ebola virus protein VP40 binding to Sec24c for transport to the plasma membrane

Nisha Bhattarai, Elumalai Pavadai, Rudramani Pokhrel, Prabin Baral, more

Proteins: Structure, Function, and Bioinformatics > 90 > 2 > 340 - 350

Outbreaks of the Ebola virus (EBOV) continue to occur and while a vaccine and treatment are now available, there remains a dearth of options for those who become sick with EBOV disease. An understanding at the atomic and molecular level of the various steps in the EBOV replication cycle can provide molecular targets for disrupting the virus. An important step in the EBOV replication cycle is the transport...

article

Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments

Jeevan B. GC, Rudramani Pokhrel, Nisha Bhattarai, Kristen A. Johnson, more

Biochemical and Biophysical Research Communications > 2017 > 493 > 1 > 176-181

Ebola virus infections cause hemorrhagic fever that often results in very high fatality rates. In addition to exploring vaccines, development of drugs is also essential for treating the disease and preventing the spread of the infection. The Ebola virus matrix protein VP40 exists in various conformational and oligomeric forms and is a potential pharmacological target for disrupting the virus life-cycle...

article

Membrane association and localization dynamics of the Ebola virus matrix protein VP40

Jeevan B. GC, Bernard S. Gerstman, Prem P. Chapagain

Biochimica et Biophysica Acta (BBA) - Biomembranes > 2017 > 1859 > 10 > 2012-2020

The Ebola virus matrix protein VP40 is a major structural protein that provides the scaffolding for new Ebola virus particles. For this, VP40 is first trafficked to the lower leaflet of the plasma membrane (PM) in its dimeric form. Once associated with the PM, the VP40 dimers undergo structural rearrangements and oligomerize into hexamers and filaments that make up the virus matrix. Therefore, association...

article

Pi(4,5)P2 Clustering by the Ebola Virus Matrix Protein VP40

Jeevan B. GC, Bernard S. Gerstman, Prem P. Chapagain

Biophysical Journal > 2017 > 112 > 3 Supplement 1 > 326a

article

Interdomain salt‐bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization

Jeevan B. GC, Kristen A. Johnson, Monica L. Husby, Cary T. Frick, more

Protein Science > 25 > 9 > 1648 - 1658

The Ebola virus protein VP40 is a transformer protein that possesses an extraordinary ability to accomplish multiple functions by transforming into various oligomeric conformations. The disengagement of the C‐terminal domain (CTD) from the N‐terminal domain (NTD) is a crucial step in the conformational transformations of VP40 from the dimeric form to the hexameric form or octameric ring structure...

article

Interdomain Interactions and the Mechanism of Structural Transformation in RfaH

jeevan B. gc, Bernard S. Gerstman, Prem P. Chapagain

Biophysical Journal > 2016 > 110 > 3 Supplement 1 > 378a

article

Ca²⁺ and Mg²⁺ modulate conformational dynamics and stability of downstream regulatory element antagonist modulator

Khoa Pham, Gangadhar Dhulipala, Walter G. Gonzalez, Bernard S. Gerstman, more

Protein Science > 24 > 5 > 741 - 751

Downstream Regulatory Element Antagonist Modulator (DREAM) belongs to the family of neuronal calcium sensors (NCS) that transduce the intracellular changes in Ca²⁺ concentration into a variety of responses including gene expression, regulation of Kv channel activity, and calcium homeostasis. Despite the significant sequence and structural similarities with other NCS members, DREAM shows several features...

article

Temperature Dependence of the Protein-Chromophore Hydrogen Bond Dynamics in the Far-Red Fluorescent Protein Mplum

Chola K. Regmi, Prem P. Chapagain, Bernard S. Gerstman

Biophysical Journal > 2014 > 106 > 2 Supplement 1 > 649a

article

Kinetics of peptide secondary structure conversion during amyloid β-protein fibrillogenesis

Timothy Steckmann, Zubair Awan, Bernard S. Gerstman, Prem P. Chapagain

Journal of Theoretical Biology > 2012 > 301 > Complete > 95-102

Amyloid fibrils are a common component in many debilitating human neurological diseases such as Alzheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE. The role of fibrillar Αβ proteins in AD has stimulated interest in the kinetics of Αβ fibril formation. Kinetic models that include reaction pathways and rate parameters for the various stages of the process can be...

article

Stabilization of Native and Non-native Structures by Salt Bridges in a Lattice Model of the GCN4 Leucine Dimer

Yanxin Liu, Prem P. Chapagain, Bernard S. Gerstman

The Journal of Physical Chemistry B > 2010 > 114 > 2 > 796 - 803

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Keywords

EBOLA VIRUS (4)
VP40 (4)
MOLECULAR DYNAMICS (2)
AΒ AGGREGATION (1)
BINDING (1)
DIMER (1)
DOCKING (1)
DREAM (1)
EF‐HAND MOTIF (1)
EQUILIBRIUM UNFOLDING (1)
FIBRILS (1)
GRAPHENE SHEET (1)
INTERDOMAIN SALT‐BRIDGES (1)
KINETIC RATE PARAMETERS (1)
LATCH‐LIKE INTERACTION (1)
LIPID INTERACTIONS (1)
MATRIX FILAMENTS (1)
MATRIX PROTEIN VP40 (1)
MEMBRANE ASSOCIATION (1)
MEMBRANE PROTEIN (1)
MOLECULAR DYNAMICS SIMULATIONS (1)
NANOTHERAPY (1)
NEURONAL CALCIUM SENSORS (1)
OLIGOMERIZATION (1)
PLASMA MEMBRANE (1)
PM LOCALIZATION (1)
POLYMERIZATION (1)
POTASSIUM CHANNEL INTERACTING PROTEIN (1)
PROTEIN (1)
ROSETTA (1)
SEC24C (1)
SECONDARY STRUCTURE (1)
TRANSFORMER PROTEIN (1)
TRYPTOPHAN EMISSION (1)
VIRUS ASSEMBLY (1)
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Elsevier (6)
Wiley (4)
ACS (1)

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