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Trypanosma brucei (T. Brucei) is an important pathogen agent of African trypanosomiasis. The flagellum is an essential and multifunctional organelle of T. Brucei, thus it is very important to recognize the flagellar proteins from T. Brucei proteins for the purposes of both biological research and drug design. In this paper, we investigate computationally recognizing flagellar proteins in T. Brucei...
Essential proteins are crucial to cellular survival and development. Traditionally, essential proteins are identified by knock-out experiments, which are expensive and often fatal to the target organisms. Regarding this, an important approach to essential protein identification is through computational prediction. In this research, we present a novel computational method, Integrated Edge Weights (IEW),...
Disease-causing genes prioritization is very important for understanding mechanisms of diseases and biomedical applications, such as drug design. Previous studies have shown that promising candidate genes are mostly ranked according to their relatedness to known disease genes or closely related disease processes. Therefore, a dangling gene (isolated gene) with no edges in the network can not be effectively...
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