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The novel HLA‐C*07:01:19 allele differs from the closest allele C*07:01:01 by a single nucleotide change at coding sequence nucleotide 738 G>A (codon 222 GAG>GAA) in exon 4.
This study used long‐range polymerase chain reaction to sequence 4.5 or 4.3 kb of genomic DNA covering human leukocyte antigen C (HLA‐C) and its flanks in 45 Chinese Han subjects to better characterize variation in the gene in a single population. Sequences of 35 HLA‐C alleles were obtained from the population, including major alleles of 13 lineages of HLA‐C. Four novel alleles, C*03:04:01:02, C*04:01:01:03,...
A novel human leukocyte antigen (HLA)‐Cw*15 variant allele was identified in a Chinese Han individual. It differs from the closest allele Cw*150201 by single nucleotide change at genomic nt 755 C>G (CDS nt 379 C>G, codon 103 CTG>GTG) in exon 3, which results in an amino acid change Leu103Val.
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