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Background
The PI3K/AKT/mTOR signaling pathway is essential for initiation and progression of prostate cancer. However, there has been no a comprehensive comparison for the role of these signaling nodes in prostate tumor initiation and progression.
Methods
With genetically engineered animal models, we compared the impact of prostate‐specific deletions of Pten, Tsc1, and Tsc2 and activation of Akt1...
The syntheses of β-amino acids 1 and 2 are presented by means of an alternative route to the asymmetric Michael-addition route reported in the preceding article. These two compounds, which bind to the α2δ subunit of calcium channels and have important medical applications, have been prepared on multi-kilogram scale in our pilot plant through a new approach that introduces the chirality at the β-carbon...
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