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Background and Objectives The infusion of thawed haematopoietic progenitor cells from apheresis (HPC‐A) is associated with minor but frequent adverse reactions (ARs), which has been mainly attributed to dimethyl sulphoxide (DMSO). Nevertheless, other factors may play a role in the pathogenesis of such toxicity.
Materials and Methods The ARs on a cohort of 423 cryopreserved HPC‐A infusions for 398...
2,2-, 3,3- and 4,4-Difluoropalmitic acids (1-3) have been synthesized and fully characterized. Acids 2 and 3 were prepared through fluorination of the corresponding dithioacetal-protected ketoesters followed by enzymatic saponification. The acids 1-3 were evaluated in vivo as inhibitors of the β-oxidation step of the biosynthesis of (Z,E)-9,11-tetradecadienyl acetate, the major component of the...
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