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Polyglutamine expansions in some proteins associated with neurodegenerative diseases, such as Huntington’s disease or several ataxias, lead to insoluble aggregates in the cell. These aggregates accumulate through a mechanism that is not yet fully understood, but it activates cell death pathways and contributes to kill the cell. Here, we show that apoptotic protease activating factor 1 (Apaf1) down-regulation,...
Purpose About 12 million people in the world live with visual impairment due to corneal diseases while there’s a shortage of corneal tissue suitable for transplantation. One of the major causes of inappropriateness of corneas to be transplanted is to have a low endothelial cell density being apoptosis a key mechanism mediating cell loss. The protein Apaf‐1 is a key regulator of the mitochondrial apoptotic...
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