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Nodal, a member of the transforming growth factor‐β superfamily, is a potent embryonic morphogen also implicated in tumor progression. Up to date structural information on the interaction of Nodal with its molecular partners are unknown. To deepen our understanding about mechanisms underlying both embryonic development and Nodal/Cripto‐dependent tumor progression, we present here a molecular model...
A strategy for the synthesis of a new hydrophilic chiral diamine derived from α-d-glucose is described. The compound is obtained by introducing proper nitrogen functions at C2 and C3 positions of the sugar ring, and by deprotecting positions 4 and 6. The efficiency of the ligand in the Rh(I)-catalysed hydrogenation of acetophenone has been examined by using isopropanol and ethanol as hydrogen sources...
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