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Based upon promising preclinical and phase 1 trial results, combined flavopiridol and cisplatin therapy was evaluated in patients with ovarian and primary peritoneal cancers.A two cohort phase 2 trial of cisplatin (60mg/m 2 IV) immediately followed by flavopiridol (100mg/m 2 IV, 24h infusion; 21day cycles) was undertaken in patients with recurrent platin-sensitive or platin-resistant...
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